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Old 06-12-2009, 11:36 AM
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Section V -- Supplementation's /Herbs

Part 1 A Closer look at Chrysin (Flavone X)


You have heard of the famous Flavone X. It has been mentioned by the famous steroid guru, Dan Duchaine. It is now available. A wholesale company called ProSource carries it. It sells for $49.95 for 60 caps. But is this supposed magical supplement? What is it all about? Well read on my curious people.

In today's quest for the leaner and meaner "hard-body", personalized supplementation is becoming almost as important as a personalized exercise program. More and more products coming into the Market are going beyond the typical blend of Branched Chain amino acids, medium chain triglycerides or other hopeful anabolic nutrients. These products promise the ability to enhance or modify existing hormonal profiles of the person taking the substance. Manipulating the production or functionality of certain hormones is the only way to deliver the results demanded by today's nutritionally educated athletes. Anabolic hormones, such as growth hormones or Insulin-like Growth Factor (IGF Series), are of interest, but testosterone seems to be the top of everyone's list. It is well known that the hormonal differences between males and females are, for the most part, responsible for the differences in overall body composition. Since men produce more testosterone than women do, there must be some correlation between leanness and higher testosterone than estrogen production. Of course, that is an oversimplification of this endocrinological phenomena, but it is the current trend in most bodybuilding circles. For the focus of this article, I will refrain from discussing the already well known and suspected testosterone-elevating compounds (i.e. Tribulus terrestris, DHEA, or Androstenedione).

From Folklore to "Wonder-Drug"
Historically, plants have enjoyed the reputation of offering various medicinal benefits. Many of these qualities can be attributed to their wide array of biologically active flavenoid compounds. A member of the passion flower family that contains chrysin, Passiflora coerulea L., is well recognized as a sedative in folklore medicine. Its beneficial effects have since been scrutinized by many drug development researchers who are looking for benzodiazepine receptor ligands (brain receptor targeted in anticonvulsant and antixyiolytic medications). These low molecular weight flavenoids also serve as a therapeutic purpose as an anti-inflammatory, anti-allergic, antiviral, antimutagenic, anticarcinogenic, but for this article, its role in modulating hepatic P-450 enzyme activity is of specific interest.

Aromatase Inhibition
Chrysin, also known as Flavone X, is structurally defined as 5,7-dihydroxyflavone. This monoflavone has generated a tremendous amount of interest due to its ability to inhibit cytochrome P-450 aromatase activity. Aromatase is an enzyme that is found in large quantities in the liver (and other tissues) and is responsible for the conversion of androstenedione and testosterones into estrogens.

This conversion is utilized by the body to keep its "gender-related" testosterone: estrogen ratios in balance. When athletes are able to supersede their "normal" production of testosterone, their aromatase activity will concomitantly rise to the challenge. This unwanted rise in estrogen concentrations may manifest a physiological change within the body (development of breast mass; "bitch-tits", shrinkage of testes, and an upregulation of fat mass deposition). Therefore, minimizing aromatase activity when elevating testosterone levels is of paramount concern. Scientific investigations have looked at the antiestrogenic activity of flavenoids but chrysin has shown the greatest dose response of all naturally occurring flavenoids. The mechanism by which this flavenoid works is by binding the active site of the enzyme, thereby blocking its ability to interact with androstendieone or testosterone. A landmark study performed by the University of California, Irvine and follow-up studies by the same group, clearly demonstrate aromatase inhibition in human tissues (in-vitro). Unfortuneately, there has not been any studies validating these responses in living humans, although the chance of seeing similar results is extremely likely.

Dosing, Clinical Side Notes and Safety.
European Olympic athletes report ingesting 1 to 3 grams daily and experiencing 30 percent increases in serum testosterone levels. Other anecdotal reports indicate that Chrysin may work best when taken with other testosterone elevating compounds (androstenedione, DHEA, and Tribulus terrestris). Unfortunately, certain combinations of these compounds currently undergoing clinical investigation are not exhibiting expected results due to unknown factors. Since this flavenoid, and those of a similar structure, are common place in our diet, moderate doses can be considered safe. On the other hand, when you consider its ability to limit an important biochemical step in estrogen production, women and to a lesser extent men, should take caution in long-term consumption of this flavenoid.

Using Chrysin in a "Cycle"
I believe that using Chrysin in a steroid cycle could be beneficial in blocking aromatization. However, if one is to use heavy doses of high androgenic steroids, then I would not even think about having Chrysin be the lone substitute for Nolvadex, Clomid or any other anti-estrogen medications. Used in conjunction would be acceptable, perhaps enhancing the steroid and the anti-estrogen. But if used with the famous Androstene, Tribestan, DHEA stack--then definitely add this to the arsenal.
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