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Old 09-04-2018, 06:10 AM
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rss IGF - A 1.week IGF-1 infusion decreases arterial insulin concentrations but increases

Related Articles A 1.week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep.

Physiol Rep. 2018 Sep;6(17):e13840

Authors: White A, Louey S, Chang EI, Boehmer BH, Goldstrohm D, Jonker SS, Rozance PJ


Abstract
Fetal insulin is critical for regulation of growth. Insulin concentrations are partly determined by the amount of ?-cells present and their insulin content. Insulin-like growth factor-1 (IGF-1) is a fetal anabolic growth factor which also impacts ?-cell mass in models of ?-cell injury and diabetes. The extent to which circulating concentrations of IGF-1 impact fetal ?-cell mass and pancreatic insulin content is unknown. We hypothesized that an infusion of an IGF-1 analog for 1.week into the late gestation fetal sheep circulation would increase ?-cell mass, pancreatic islet size, and pancreatic insulin content. After the 1-week infusion, pancreatic insulin concentrations were 80% higher than control fetuses (P.
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