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Old 02-18-2018, 07:20 AM
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rss IGF - Aerobic exercise inhibits obesity-induced respiratory phenotype.

Related Articles Aerobic exercise inhibits obesity-induced respiratory phenotype.

Cytokine. 2018 Feb 14;104:46-52

Authors: Aquino-Junior JCJ, MacKenzie B, Almeida-Oliveira AR, Martins AC, Oliveira-Junior MC, Britto AA, Arantes-Costa FM, Damaceno-Rodrigues NR, Caldini EG, de Oliveira APL, Guadagnini D, Leiria LO, Ricardo DR, Abdalla Saad MJ, Vieira RP


Abstract
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation.
METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n.=.15). A classical model of diet-induced obesity (DIO) over 12.weeks was used. AE was performed 60.min/day, 5.days/week for 5.weeks. Airway hyperresponsiveness (AHR), lung inflammation and remodeling, adipokines and cytokines in bronchoalveolar lavage (BAL) was determined.
RESULTS: A high fat diet over 18.weeks significantly increased body weight (p.
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