World Class Bodybuilding   Forum

BulkSupplements Egg Whites International A1Supplements.com i-Supplements Strength.com VitaSprings Myprotein Beyondsupplements
Go Back   World Class Bodybuilding Forum > WorldClass RSS Feeds > Peptides RSS FFEDS

Shoutbox
Loading...





Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 02-20-2018, 04:40 PM
Bodybuilding Peptides's Avatar
Bodybuilding Peptides Bodybuilding Peptides Is Off Line
Sponsor

 
Join Date: Feb 2009
Posts: 5,619
Thanks: 1
Thanked 32 Times in 23 Posts
Rep Power: 194
Bodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to behold
rss IGF - Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neuro

Related Articles Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function following Traumatic Brain Injury.

J Neurotrauma. 2018 Feb 17;:

Authors: Carlson SW, Saatman KE

Abstract
Traumatic brain injury (TBI) produces neuronal dysfunction and cellular loss that can culminate in lasting impairments in cognitive and motor abilities. Therapeutic agents that promote repair and replenish neurons after TBI hold promise in improving recovery of function. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice; however, the translational neurogenic potential of exogenously administered IGF-1 after TBI remains unknown. In a mouse model of controlled cortical impact (CCI), continuous intracerebroventricular infusion of recombinant human IGF-1 (hIGF) for 7 days, beginning 15min post-injury, resulted in a dose-dependent increase in the number of immature neurons in the hippocampus. Infusion of 10?g/d IGF-1 produced detectable levels of hIGF-1 in the cortex and hippocampus and a concomitant increase in Akt activation in the hippocampus. Both motor function and cognition were improved over 7 days following injury in IGF-1 treated cohorts. Vehicle treated brain-injured mice showed reduced hippocampal immature neuron density relative to sham controls at 7 days post-injury. In contrast, the density of hippocampal immature neurons in brain-injured mice receiving acute onset IGF-1 infusion was significantly higher than in injured mice receiving vehicle and equivalent to that in sham-injured control mice. Importantly, the neurogenic effect of IGF-1 was maintained with as much as a 6 hr delay in the initiation of infusion. These data suggest that central infusion of IGF-1 enhances the generation of immature neurons in the hippocampus, with a therapeutic window of at least 6 hrs post-injury, and promotes neurobehavioral recovery after TBI.


PMID: 29455576 [PubMed - as supplied by publisher]



More...
Insulin like growth factors
IGF-1
Igf-1r3

This has been a World Class Bodybuilding automated thread
__________________
W C B B Affiliates

PowderCity.com <---Best Selling Products
BulkSupplements.com <---Save Money, Buy in BULK
IslandSupplements.com <--- Latest Sale Items
I-supplements.com <--- Vip Special Offers
A1Supplements.com <----Clearance Supplements
HideMyAss Security Proxy<---- Protect your online activity
Home Chemistry Conversions <-- home chemistry needs
Help WCBB by using our AMAZON.com link use for any amazon purchase.
Egg Whites International <---100% Bio-Available Egg White Protein
Liquid egg whites recipes ,-- protein shakes, smoothies, full delicious meals etc.
Egg White Fitness Website <-- Site all about Egg Whites
WorldClassBodyBuilding Teeshirts <-- get your WCBB t-shirts here, first design to latest
Reply With Quote
Get your liquid egg whites here at EGG WHITES INTERNATIONAL

Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 01:46 AM.



Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
follow worldclassbodybuilding at facebook follow worldclassbodybuilding at pinterest follow worldclassbodybuilding at twitter