Enhancing Healing with BPC-157

[basskiller]

Enhancing Healing with BPC-157
bpc-157

BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice.
Experiments have shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats. The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an injured tendon. The study used two group of tendon explants of which one group was cultured in a BPC 157-containing medium while the other group was cultured in a medium lacking BPC 157.

These cultures were thereafter examined for tendon fibroblasts outgrowths. Such outgrowths indicated tendon regeneration. The results revealed that the explants’ outgrowth was significantly accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157. Also, a MTT assay did show that BPC 157 does not directly affect cellular proliferation in a culture of rat-derived Achilles tendon. However, results also showed that BPC 157 significantly increased the survival of cells under oxidative stress.

Furthermore, the Transwell filter migration assay showed that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.

Additionally, FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
Thus, it can be concluded that BPC 157 enhances the ex-vivo growth and in-vitro cellular migration of fibroblasts derived from tendon explants. Moreover, BPC 157 also increases the probability of a cell surviving under oxidative stress. These actions of BPC 157 are probably mediated by the activation (through phosphorylation) of the proteinic FAK-paxillin pathway.

[liftsiron]

It really seems to work for me!

[3Vandoo]

does it always needs to be a 1g... dose a week or every day injection is ok?

[Txrebel]

500 mcg a day seems to be enough

250 morning 250 night

[MR. BMJ]

Been taking 200mcg BID for the last 2 or so months, and I think it is helping with my receiting gums.

Been using it in my shoulders and traps. Not sure how much it is helping, but going for a long term approach.

[Dakota]

I used up to 1,500 week. It seems to kick in about 1,000. It is my opinion that there was a lot of help in healing.

[Friggemall]

Originally Posted by Dakota

I used up to 1,500 week. It seems to kick in about 1,000. It is my opinion that there was a lot of help in healing.

I am doing 250/ed for my left elbow now for close to a month. Not seeing much help but I'm sticking to it.