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Old 05-17-2018, 05:32 AM
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rss Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid

Related Articles Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study.

Electron Physician. 2018 Mar;10(3):6500-6505

Authors: Lashkari M, Noori A, Oveisi S, Kheirkhah M


Abstract
Background: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA.
Objective: The aim of this study was to determine the association of serum testosterone and DHEAs with RA.
Methods: This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were considered as abnormal. DHEAs levels lower than 18.9 ?g/dl in females and 88.9 ?g/dl in males were considered as abnormal. Data were analyzed using independent sample T-test, Chi-square test, and logistic regression analysis by SPSS software, version 19.
Results: The mean testosterone level in females of the control group was significantly higher than females in the case group. The mean DHEAs in the control group was significantly higher than the case group. Abnormal testosterone and DHEAs level in the case group was significantly higher than the control group. Logistic regression analysis showed independent association only between DHEAs levels and RA, after adjusting for age and gender (OR: 0.966, 95% CI: 0.953-0.979; p
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