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Old 10-13-2018, 05:10 AM
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rss Flow mediated vasodilation assay indicates no endothelial dysfunction in hereditary a

Flow mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency.

Ann Allergy Asthma Immunol. 2018 Oct 09;:

Authors: Nebenführer Z, Szabó E, Kajdácsi E, K?halmi KV, Karádi I, Zsáry A, Farkas H, Cervenak L

Abstract
BACKGROUND: Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare, potentially life-threatening disorder characterized by recurrent edematous attacks. The edema formation is the consequence of interaction of bradykinin and various vasoactive peptides with endothelium. Besides these agents, danazol, a modified testosterone derivative used in these patients to prevent edematous attacks, can also affect the function of the endothelium, since it shifts the blood lipid profile to a pro-atherogenic phenotype.
OBJECTIVE: To assess the endothelial function in C1-INH-HAE patients and in healthy matched controls.
METHODS: To evaluate the endothelial function, we used the flow mediated dilation method measured in the region of the brachial artery in 33 C1- INH-HAE patients and in 30 healthy matched controls. Laboratory measurements of standard biochemical parameters were performed on computerized laboratory analyzers.
RESULTS: There was no difference in endothelial function (reactive hyperaemia, RH) between patients (median 9.0, 25-75% percentile 6.3-12.9) and controls (median 7.37, 25-75% percentile 4.52-9.93). Although we found elevated cardiovascular risk (high BMI and LDL/HDL ratio) in danazol treated C1-INH-HAE patients, RH values did not differ between danazol treated and non-treated patients. Furthermore, risk factors correlated with the endothelial function only in healthy controls and patients not treated with danazol.
CONCLUSION: In summary, our results did not indicate any signs of endothelial dysfunction in C1-INH-HAE patients. Moreover, the normal endothelial function in danazol treated patients with pro-atherogenic lipid profile suggests that elevated bradykinin level or other factor(s) involved in the pathogenesis of edematous attacks may have a protective role against endothelial dysfunction and atherosclerosis.


PMID: 30312677 [PubMed - as supplied by publisher]



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