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Old 02-01-2022, 11:32 AM
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Myostatin Inhibitors

I was watching Just Bodybuilding Podcast yesterday and they talked a little about myostatin inhibitors. From what I gather there are no safe and effective myostatin inhibiting drugs developed yet, as they cannot isolate inhibition of myostatin for muscles, so organs will grow as well. The question is do you think they will ever figure it out? If they do, will this bring bodybuilding to a whole new level? I have seen what myostatin inhibitors have done to animals and it is freaky.
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Old 02-01-2022, 11:44 AM
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I never underestimate the ability of researchers to come up with something. After 34 years at a research university, I saw some pretty amazing things developed. With that and the intelligence of new students entering college, specifically research universities where they are getting involved in research programs at the freshmen level I feel it is possible.
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Old 02-01-2022, 12:05 PM
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Quote:
Originally Posted by Genetic Freak View Post
I was watching Just Bodybuilding Podcast yesterday and they talked a little about myostatin inhibitors. From what I gather there are no safe and effective myostatin inhibiting drugs developed yet, as they cannot isolate inhibition of myostatin for muscles, so organs will grow as well. The question is do you think they will ever figure it out? If they do, will this bring bodybuilding to a whole new level? I have seen what myostatin inhibitors have done to animals and it is freaky.
If I recall correctly, Flex Wheeler had a naturally occurring myostatin mutation that helped him achieve his nearly perfect physique early in his career.
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Old 02-01-2022, 12:47 PM
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This review covers avenues into myostatin as a target.

https://www.ncbi.nlm.nih.gov/labs/pm...es/PMC8444957/
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Old 02-01-2022, 01:29 PM
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Quote:
Originally Posted by Glycomann View Post
This review covers avenues into myostatin as a target.

https://www.ncbi.nlm.nih.gov/labs/pm...es/PMC8444957/
Good read brother. I read some older studies (5-10 years old) and it appears we are getting closer.
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Old 02-01-2022, 03:04 PM
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I remember watching some show on biohackers. Many experimented on themselves too. But I do remember one guy that developed a myostatin blocker and took it. A few times. But it didn’t work. Now he didn’t lift weights or anything but with myostatin blocked I don’t think u even need to. Anyways. Who knows what he injected. It didn’t work. Lol. I wish I could remember what other genes they were messing with. It was pretty interesting.
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Old 02-01-2022, 03:24 PM
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I've been experimenting with Epicatechin for about five months now (1000mg daily, PWO if a workout day). I think it's safe to say it does not do anything but cost money.

This post just made me do some further digging and immediately ran across a study showing there was no effect whatsoever on myostatin (at 200mg anyway), and it in fact inhibited aerobic adaptations that would normally occur from exercise. Fantastic. I'm binning it. I realize studies are a dime a dozen, but after five months and no results (I should look like a double-muscled whippet by now), I'm done with it.

Last edited by beefnewton; 02-01-2022 at 03:33 PM.
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Old 02-02-2022, 05:30 AM
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Interesting topic. I remember the myostatin inhibitor you could get at GNC made from tomatoes or such. I bought some, I was a sucker.
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Old 02-03-2022, 09:26 AM
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i always think first, we sent a man to the moon......what is next

i think they will do it, don't know when, think the same of alzheimers, cancer now with immunotherapy is friggin light year magic stuff....no one talks about it due to the age, the results were off the charts day one and continue that way 6 years later, one day they will finally say....okay, we can trust it, lol

here is what i know, is i will not probably do it.....i am aging like fine wine, don't need nuthing to mess it up
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Old 06-15-2022, 12:17 PM
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I've been putting in a lot of time reading up on myostatin inhibitors and I've been using follistatin and YK11 lately, along with trestolone, test, anadrol and 2iu gh. Here's a summary.
1) In transgenic animals and fish, follistatin causes hyperplasia and hypertrophy
2) In normal (non-trans) animals (humans, too I guess), follistatin causes hypertrophy only. The fibers thicken. There is a question of how permanent is that result. I know with training, nutrition, and PEDs, you can certainly extend it. In short, most of the bros overlook the fact about hyperplasia and hypertrophy. It's important.
3) The main myostatin inhibitors are: follistatin, gdf-8 (myostatin HMP), ACE031 (and 083), and YK11. Of them, ACE works only locally. The others are systemic.

My results: folli & yk11 seem to work along with the steroids. I stopped the folli a few days ago and and jumped up the YK from 15mg 3x per day to 20mg 2x per day. The YK seems, along with anadrol, seems to be causing me some fat loss, but not weight loss. From here, my thinking is about hyperplasia. I don't imagine 2iu of gh is doing all that much. Next time, I'll add peg-mgf.
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