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Old 09-21-2011, 03:49 PM
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Exclamation Warning: 7,8-Benzoflavone Is Carcinogenic

Warning: 7,8-Benzoflavone Is Carcinogenic

Top Form Secrets: Warning: 7,8-Benzoflavone Is Carcinogenic

There is a compound used by bodybuilders that acts as a powerful aromatase inhibitor, reducing estrogen and allowing users to be less estrogen dominant. The substance, however, has been demonstrated to be carcinogenic. The substance is 7,8-Benzoflavone. The following line of reasoning demonstrates that 7,8-Benzoflavone may be carcinogenic in humans.


Benzo[a]pyrene is "highly carcinogenic." Benzo[a]pyrene is found in cigarette smoke, car exhaust fumes, "marijuana smoke, incense smoke, wood smoke, and in charbroiled food." It is even in burnt toast.1
"A vast number of studies over the previous three decades have documented links between benzo[a]pyrene and cancers."1
7,8-Benzoflavone has been demonstrated in rat studies to "stimulate . . . benzo(a)pyrene tumorigenesis." In some cases 7,8-Benzoflavone reduces cancer, but in others (such as when it is applied topically with benzo(a)pyrene) it increases cancer.2

Although 7,8-Benzoflavone is an aromatase inhibitor, preventing the conversion of testosterone into estrogen, and in some cases preventing cancer,3-5 the fact that 7,8-Benzoflavone has a double nature and is, in other cases, carcinogenic6-9 (such as when it is combined with benzo[a]pyrene), should make us think twice before using it in humans.





References

Benzopyrene - Wikipedia, the free encyclopedia
Proc. Nat. Acad. Sci. Vol. 69, No. 4, pp. 824-828, April 1972. Aryl Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding. (benzo(a)pyrene/7,12-dimethylbenz(a)anthracene/DNA, RNA, and protein binding/mouse skin). Nadao Kinoshita and Harry V. Gelboin. Available online at: Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding (Accessed Nov. 5, 2008.)
Progress in Medicinal Chemistry. By G. P. Ellis, Geoffrey Buckle West. P. 59. Published by Elsevier, 1988. Progress in Medicinal Chemistry - G Ed Ellis - Google Books (Accessed Nov. 5, 2008.)
Action of 7,8-benzoflavone on incidence of skin tumors induced by polycyclic hydrocarbons. Bulletin of Experimental Biology and Medicine. NY: Springer. Issue Volume 87, Number 5 / May, 1979. DOI 10.1007/BF00806687. Pp. 474-475. December 13, 2004. Online at: SpringerLink - Bulletin of Experimental Biology and Medicine, Volume 87, Number 5 (Accessed Nov. 6, 2008.)
Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice. Alworth WL, Slaga TJ. Carcinogenesis. 1985 Apr.6(4):487-493. Effects of ellipticine, flavone, and 7,8-benz... [Carcinogenesis. 1985] - PubMed - NCBI (Accessed Nov. 6, 2008.)
Role of Metabolic Activation in the Carcinogenicity of Estrogens: Studies in an Animal Liver Tumor Model. Manfred Metzler, Günter Blaich, and Angelika M. Tritscher. Environmental Health Perspectives. August. Vol. 88, pp. 117-121, 1990. Role of metabolic activation in the carcinogenicity of estrogens: studies in an animal liver tumor model.. (Accessed Nov. 6, 2008.)
The author of a review states that "7,8-benzoflavone actually appears to enhance tumor formation by benzo(a)pyrene . . . indicating the complex interaction of effects of benzoflavones upon various cutaneous polycyclic aromatic hydrocarbon metabolizing enzymes." [Emphasis supplied.] Dermal Absorption and Toxicity Assessment. By Michael S. Roberts, Kenneth A. Walters. Informa Health Care, 1998, p. 76. Online at: Dermal absorption and toxicity ... - Michael S. Roberts, Kenneth A. Walters - Google Books (Accessed Nov. 7, 2008.)
7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver. Biochem Biophys Res Commun. 1978 May 15;82(1):348-55. Buening MK, Fortner JG, Kappas A, Corney AH. Available online at: 7,8-Benzoflavone stimulates the m... [Biochem Biophys Res Commun. 1978] - PubMed - NCBI. (Accessed Nov. 7, 2008.)
Yet another study comes to a rather frightening conclusion for those who have been using 7,8-Benzoflavone, indicating that “the addition of . . . 7, 8-benzoflavone to human liver microsomes caused a many-fold stimulation in the hydroxylation of benzo(a)pyrene, the metabolism of aflatoxin B1 to 2,3-dihydro-2,3-dihydroxyaflatoxin B1, and the metabolic activation of aflatoxin B1 to mutagenic products.” [Emphasis supplied.] “Activation and Inhibition of Benzo(a)pyrene and Aflatoxin B1 Metabolism in Human Liver Microsomes by Naturally Occurring Flavonoids.” Mildred K. Buening, Richard L. Chang, Mou-Tuan Huang, Joseph G. Fortner, Alexander W. Wood, and Allan H. Conney. Cancer Research 41, 67-72, January 1981. Available online at Activation and Inhibition of Benzo(a)pyrene and Aflatoxin B1 Metabolism in Human Liver Microsomes by Naturally Occurring Flavonoids (Accessed Nov. 7, 2008.)


Posted by Marilyn Christian at Wednesday, November 05, 2008
4 comments:
stkm said...
GOOD INFORMATION.As a physician i would like to complement on ur efforts.

November 12, 2008 8:33 AM
Anonymous said...
You are not a physician, if you were you would know that this person knows jack shit all about this. They can't spell and seem to miss the point that 7,8 benzo is very different from benzopyrenes.

October 8, 2009 2:09 PM
Anonymous said...
This is really a bad interpretation of data.

October 31, 2009 7:25 AM
Anonymous said...
These papers say nothing about benzoflavone being toxic, just that they potentially worsen the effect of the poison aflatoxin. Aflatoxin isn't part of the standard diet in any form, in fact we have laws in the US to prevent aflatoxins from being in the food supply. So, the headline "benzoflavone is carcinogenic" is 100% misleading and false. None of the papers cited seem to show benzoflavones as being carcogens at all.

October 31, 2009 7:40 AM
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Old 09-22-2011, 07:15 AM
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This is one of Sustain alpha S4 ingredients, which everyone uses for PCT.
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Old 09-22-2011, 09:21 AM
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I've read a couple places rebuking this statement Where they highilghted a few areas showing this isn't true. I'll try to find them.
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Old 09-22-2011, 10:53 AM
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Originally Posted by Thunder View Post
I've read a couple places rebuking this statement Where they highilghted a few areas showing this isn't true. I'll try to find them.
Please do so. I'm planning on running it soon. thanks
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Old 09-22-2011, 11:30 AM
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Is this the article/write up?

October 14th, 2009 – A search on Google for 7,8-benzoflavone yields a link to a blogger who appears to have the opinion that 7,8-benzoflavone is a dangerous carcinogenic substance. They based this opinion on several studies which combined high levels of well known cancer causing substances, with 7,8-benzoflavone. They provided no references showing 7,8-benzoflavone is a carcinogenic substance in and of itself.

The first reference discusses the carcinogenbenzo[a]pyreneas being highly carcinogenic and that when combined with 7,8-benzoflavone, this can increase the rate of tumor formation. While this is true, this particular study foundzero tumor formation when 7,8-benzoflavone was used alone, and it in fact inhibited tumor formation caused by the more potent carcinogen7,12-dimethylbenz(a)anthracene(DMBA), thus offering a net protective effect against tumor formation. (1)

Other studies have also shown 7,8-benzoflavone has protective effects against cancer by inducing 2-hydroxylation of estrogens, thus increasing the clearance of estrogens and reducing cancer risk. (2-4)

Isolating flavonoids and carcinogens together in an in-vitro environment is a popular cancer research practice for studying the metabolism of cancer causing substances. Virtually all natural flavonoids (exp., quercetin, tangeretin, chrysin or nobiletin) have been found to negatively or positively metabolize carcinogenic chemicals in special test tube environments. However the research clearly shows a net anti-cancer effect from naturally occurring flavones. (5-7)


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References

1. Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding.
Nadao Kinoshita et al.
Proc Natl Acad Sci U S A. 1972 April; 69(4): 824-828

2. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone
GE Schwab, JL Raucy and EF Johnson
Volume 33, Issue 5, pp. 493-499, 05/01/1988

3. Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.
M Rahman, C Hayes Sutter, GL Emmert, and TR Sutter
Toxicol Appl Pharmacol, November 1, 2006; 216(3): 469-78.

4. Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland
Misty Prince, Cheryl T. Campbell, Taylor A. Robertson, Amy J. Wells, and Heather E. Kleiner
Carcinogenesis, Jun 2006; 27: 1204 – 1213.

5. Dietary Flavonoids and the Risk of Colorectal Cancer
Evropi Theodoratou, et al.
Cancer Epidemiol. Biomarkers Prev., Apr 2007; 16: 684 – 693

6. Flavonoids and the Risk of Oral and Pharyngeal Cancer: A
Case-Control Study from Italy
Lagiou, et al.
Cancer Epidemiol. Biomarkers Prev., Aug 2007; 16: 1621 – 1625.

7. A Review of the Epidemiological Evidence on Tea, Flavonoids, and Lung Cancer
Ilja C. W. Arts
J. Nutr., Aug 2008; 138: 1561S – 1566S
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