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Old 01-23-2020, 06:16 AM
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rss IGF - The role of serum growth hormone and insulin-like growth factor-1 in adult huma

The role of serum growth hormone and insulin-like growth factor-1 in adult humans brain morphology.

Aging (Albany NY). 2020 Jan 22;12:

Authors: Yuan T, Ying J, Jin L, Li C, Gui S, Li Z, Wang R, Zuo Z, Zhang Y


Abstract
Growth hormone (GH) and its anabolic mediator, insulin-like growth factor-1 (IGF-1), have a critical role in the central nervous system. However, their detailed roles in the adult human brain are not clear. In this study, structural MRIs of 48 patients with GH-secreting pituitary adenoma (GH-PA), 48 sex- and age-matched clinical Non-Functional pituitary adenoma patients (NonFun-PA) and healthy controls (HCs) were assessed using voxel-based morphometry (VBM) and region-based morphometry (RBM). Correlation analyses helped determine the relationships between serum hormone levels and brain structure. The whole-brain gray matter volume (GMV) and white matter volume (WMV) significantly increased at the expense of cerebrospinal fluid volume (CSFV) in GH-PA (Bonferroni corrected, p
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