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Old 02-14-2020, 06:01 AM
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rss IGF - Exercise and IGF-1 supplementation improve angiogenesis and angiogenic cytokine

Related Articles Exercise and IGF-1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy.

Exp Physiol. 2020 Feb 13;:

Authors: Saboory E, Gholizadeh-Ghaleh Aziz S, Samadi M, Biabanghard A, Chodari L

Abstract
NEW FINDINGS: What is the central question of this study? Do changes in the level of angiogenesis related mediators (VEGF-A, TSP-1 and NF-?b) in sciatic nerve mediate diabetic neuropathy in the Streptozotocin-induced type 1 diabetic male rat? Can exercise and IGF-I treatment improve diabetes related-decreased angiogenesis in the sciatic nerve of Streptozotocin-induced type 1 diabetic male rat? What is the main finding and it's important? VEGF-A, TSP-1 and NF-?b levels change in the sciatic nerve of diabetic rats and may mediate diabetic neuropathy. Treatment with IGF-I and exercise could increase angiogenesis in the diabetic rats by increasing VEGF-A as well as decreasing TSP-1 and NF-?b expression in the sciatic nerve.However, combination therapy didn't show any additive effect on angiogenesis or VEGF-A, TSP-1 and NF-?b levels in the sciatic nerve of the diabetic rats compared with eachtreatmrnt alone.
ABSTRACT: Background Diabetic neuropathy is a severe complication of diabetes , affecting 40-50% of diabetic people in the world. This study aimed to characterize angiogenesis alterations and related molecular mediators in the sciatic nerve under diabetic conditions alone or in combination with.exercise and insulin-like growth factor 1 (IGF-1) administration. Methods Forty male Wistar rats were assigned into one of five groups, namely control, diabetes, diabetes+exercise, diabetes+IGF-1, and diabetes+exercise+IGF-1. Type 1 diabetes was induced by intraperitoneal injection of 60.mg.kg-1 of streptozotocin. After 30 days of treatment with exercise or IGF-I alone or in combination, diabetic neuropathy was evaluated by a hot plate, HbA1c was measured, angiogenesis was determined by immunostaining for PECAM-1/CD31, and expressions of vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor kappa B (NF-?b) were determined by ELISA. Results After four weeks, the diabetes group showed a significant decrease in capillary density and VEGF-A levels, but a significant increase.in HbA1c in blood, TSP-1 and NF-?b levels in the sciatic nerve compared to the control group, whereas these effects were reversed by exercise and IGF-1. However, simultaneous treatment of diabetic rats with IGF-I and exercise did not have any synergistic effects. Conclusions These findings indicate that diabetes-induced neuropathy may in part be associated with decreased.angiogenesis mediated by overproduction of TSP-1 and NF-?b, as well as reduced production of VEGF-A proteins. The findings also showed that exercise and IGF-I can reduce neuropathy followed by increased angiogenesis by change of TSP-1, NF-?b and VEGF-A production levels. This article is protected by copyright. All rights reserved.


PMID: 32053260 [PubMed - as supplied by publisher]



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