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Old 09-30-2016, 07:00 AM
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rss Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Ma

Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice.

J Cell Biochem. 2016 Sep 28;

Authors: Ponnusamy S, Sullivan RD, Thiyagarajan T, Tillmann H, Getzenberg RH, Narayanan R

Abstract
OBJECTIVES: To evaluate two selective androgen receptor modulators (SARMs) (GTx-024 and GTx-027) in a post-menopausal animal model in order to determine their effect on pelvic floor muscles. Stress urinary incontinence (SUI), a prevalent condition, is represented by an involuntary leakage of urine that results, at least in part, from weakened or damaged pelvic floor muscles and is triggered by physical stress. Current treatment options are limited with no oral therapies available. The pelvic floor is rich in androgen receptor and molecules with anabolic activity including (SARMs) may serve as therapeutic options for individuals with SUI.
METHODS: Female C57BL/6 mice were ovariectomized and their pelvic muscles allowed to regress. The animals were then treated with vehicle or doses of GTx-024 or GTx-027. Animal total body weight, lean body mass and pelvic floor muscle weights were measured along with the expression of genes associated with muscle catabolism.
RESULTS: Treatment with the SARMs resulted in a restoration of the pelvic muscles to the sham-operated weight. Coordinately, the induction of genes associated with muscle catabolism was inhibited. Although a trend was observed towards an increase in total lean body mass in the SARM- treated groups, no significant differences were detected.
CONCLUSIONS: Treatment of an ovariectomized mouse model with SARMs resulted in an increase in pelvic floor muscles, which may translate to an improvement of symptoms associated with SUI and serves as the basis for evaluating their clinical use. This article is protected by copyright. All rights reserved.


PMID: 27681158 [PubMed - as supplied by publisher]



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