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Old 09-15-2018, 06:10 AM
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rss Prostaglandin E2 triggers cytochrome P450 17? hydroxylase overexpression via signal t

Related Articles Prostaglandin E2 triggers cytochrome P450 17? hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.

Oncol Lett. 2018 Oct;16(4):4577-4585

Authors: Ke J, Shen Z, Li M, Peng C, Xu P, Wang M, Zhu Y, Zhang X, Wu D


Abstract
Prostaglandin E2 (PGE2) is the most common prostaglandin in the human body, meaning that its malfunction impacts on the development of numerous diseases. Prostaglandin E synthase 2 (PTGES2) is involved in the synthesis of PGE2. In the present study, immunohistochemistry of PTGES2 was performed in 152 patients with endometrial cancer and in 66 patients with normal endometria. The results indicate a notable association among increased expression of PTGES2 and age (P=0.0092) and the depth of myometrial invasion (P
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