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  #1  
Old 01-12-2018, 08:54 AM
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B6 and reduced prolactin

massive G jogged my memory about B6 being a prolactin inhibitor in one of his threads.

I googled this and found the correct kind of B6 to take for the desired effect. We know prolactin can kill sex drive.

Here is the pub med on it

https://www.ncbi.nlm.nih.gov/pubmed/501547
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Old 01-12-2018, 09:38 AM
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Be careful. Some of the literature shows no effect. I would say try it and see. What can it hurt? This French study found no significant effect in humans but didn't really use a whole lot of it.

Ann Endocrinol (Paris). 1980 May-Jun;41(3):215-7.
Lack of effect of oral pyridoxine on TRH and chlorpromazine induced prolactin secretion.

Vandeweghe M.
Abstract
In view of the controversial action of pyridoxine on prolactin dynamics, the plasma prolactin response to TRF and chlorpromazine was evaluated in normal adults before and after one week of pyridoxine per os (750 mg daily). No statistically significant blunting effect of pyridoxine pretreatment could be demonstrated in either of both test procedures.
PMID: 6774657
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Old 01-12-2018, 09:40 AM
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On the other hand, I used caber for a few weeks and had blood work done about 6 weeks later and my prolactin was still not measurable.
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Old 01-12-2018, 09:46 AM
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Here is a not bad article on prolactin in men if any are interested.

https://www.omicsonline.org/open-acc....php?aid=66774
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Old 01-13-2018, 11:37 AM
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Thanks glyco. I did read that the context behind the different studies is type of B6. That is how they found that Pyridoxine hydrochloride was the only one found to suppress prolactin.
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Old 01-13-2018, 06:36 PM
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I sifted through some abstracts and it seemed like there wasn't a clear cut answer even when Pyridoxine hydrochloride was used. But I have heard a lot of guys seem to feel it works for them.
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Old 01-14-2018, 11:42 AM
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Quote:
Originally Posted by Glycomann View Post
I sifted through some abstracts and it seemed like there wasn't a clear cut answer even when Pyridoxine hydrochloride was used. But I have heard a lot of guys seem to feel it works for them.

thanks for spending the time glyco. anecdotal evidence from "a lot" of guys means there is at least SOME truth to it IMO. Obviously not as effective as caber but things like this are cumulative in their effects. A bunch of little things add up to one big thing.
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Old 01-14-2018, 12:37 PM
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I know liftsiron has been preaching the the success of this with him for years.
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Old 01-14-2018, 01:52 PM
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Been using it for years to that effect. It has demonstrated neurotoxicity in high levels for longer periods but I've always found acute servings to be fine
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Old 01-14-2018, 03:28 PM
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Studies on B6 Effectivness on Prolactin
======================================
J Clin Endocrinol Metab 1976 Mar;42(3):603-6


Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.

Delitala G, Masala A, Alagna S, Devilla L.

A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.

===============================
N Engl J Med 1982 Aug 12;307(7):444-5

Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.

Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.

=====================================
Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8

[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]

[Article in Italian]

Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.

The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other authors appear to prove.
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Here is one on Bromo.

Journal of Clinical Endocrinology & Metabolism, Vol 42, 1024-1030, Copyright © 1976 by Endocrine Society


--------------------------------------------------------------------------------

ARTICLES


Prolactin and thyrotropin responses to thyrotropin-releasing hormone in patients with secondary amenorrhea: the effect of bromocriptine
E Hirvonen, T Ranta and M Seppala


Prolactin (PRL) and thyrotropin (TSH) responses to a 200 mug intravenous thyrotropin-releasing hormone (TRH) bolus were measured by radioimmunoassay in 11 women with hyperprolactinemic amenorrhea and 9 with normoprolactinemic amenorrhea. In all cases, the tests were carried out under basal conditions and repeated during bromocriptine treatment. In women whose basal PRL level was normal; TRH caused a maximal PRL increment of 85 +/- 25.2 mug/l (mean +/- SE), while those women whose basal PRL level was raised showed a smaller increase (5.2 +/- 11.9 mug/l) (P=0.02). The peak levels were not significantly different in these two groups (95.0 +/- 26.7 and 134.6 +/- 35.9 mug/l) (P is greater than 0.1). During bromocriptine treatment, the raised PRL levels decreased in all cases, but levels over 30 mug/l remained in 3 patients, one of whom turned out to have a pituitary tumor. Prolactin responses to TRH were markedly inhibited in normoprolactinemic patients by the dose of bromocriptine used. The mean maximal net increase of PRL was 2.0 +/- 0.9 mug/l in normoprolactinemic patients and 11.0 +/- 8.1 mug/l in hyperprolactinemic patients taking bromocriptine. After TRH stimulation during bromocriptine, the peak PRL levels in hyperprolactinemic patients were higher (32.7 +/- 10.5 mug/l) than in normoprolactinemic patients (7.2 +/- 1.5 mug/l). Unlike what has been described for hypothyroid patients, the basal TSH level in euthyroid amenorrhea patients was not affected by bromocriptine, and we found that bromocriptine has no effect on the TRH-TSH response.
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Here is another one for B6.
Journal of Clinical Endocrinology & Metabolism, Vol 42, 1192-1195, Copyright © 1976 by Endocrine Society


--------------------------------------------------------------------------------

ARTICLES


Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6)
EN McIntosh


Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day). In each the galactorrhea ceased and serum prolactin levels were maintained in the normal range while taking pyridoxine. In two other women with prolonged secondary amenorrhea but without hyperprolactinemia or galactorrhea, pyridoxine at dosages up to 600 mg/day did not restore ovulatory menses. Pyridoxine treatment was also ineffective in decreasing profuse galactorrhea in one woman with normal prolactin levels and regular ovulatory menses. In the three women effectively treated with pyridoxine, the galactorrhea returned, serum prolactin levels increased, and the menses ceased after discontinuing pyridoxine. These results imply that pyridoxine, by decreasing the excessive secretion of prolactin, may be useful in the long-term medical management of women with hyperprolactinemia and the galactorrhea-amenorrhea syndrome.
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