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Old 08-11-2018, 07:12 AM
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rss IGF - Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/?-Catenin in Androgenetic Alopecia.

Dermatol Surg. 2018 Aug 09;:

Authors: Meephansan J, Ungpraphakorn N, Ponnikorn S, Suchonwanit P, Poovorawan Y

Abstract
BACKGROUND: A new treatment for androgenetic alopecia (AGA) is 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth.
OBJECTIVE: The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/?-catenin in patients with AGA.
METHODS: Twenty-three patients with AGA were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected.
RESULTS: Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed.
CONCLUSION: The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with AGA. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/?-catenin or IGF-1 expression.


PMID: 30096107 [PubMed - as supplied by publisher]



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