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Old 10-18-2019, 05:28 PM
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Metformin blunts muscle hypertrophy in response to progressive resistance training

For those of you considering Metformin as an anti-aging tool. Take this into consideration. The trade off might be worth it depending on your age and/or goals, but it's worth putting out there.

https://peterattiamd.com/191013/
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Old 10-18-2019, 11:57 PM
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i wonder if anabolics cancel out the anti hypertrophy effect of metformin? anyone noticed a difference in gains while on AS w/ metformin vs without metformin?
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Old 10-19-2019, 10:35 AM
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Originally Posted by Druss View Post
i wonder if anabolics cancel out the anti hypertrophy effect of metformin? anyone noticed a difference in gains while on AS w/ metformin vs without metformin?
I do not think so. I think you will still have the anabolic/androgenic benefits of the AS but the metformin will still hinder gains as to which you would normally get from hypertrophy.

So instead of getting double the results over training natty you may get .5 instead.

Plenty of supps that help longevity.

Such as nicotinamide riboside, but it too blunts exercise induced growth. I think it is nature of the beast. Supps that reduce inflammation and help protect against oxidative stresses adversely effect gains. Even vitmain c has an effect although it is totally negligible and is still a great supp.
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Old 10-23-2019, 12:39 PM
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Give this a listen to before you give metformin a death sentence! Great podcast entirely on the subject and addresses what your referring to with metformin as well as effects vs benefits ratio, and as addresses the fact that you have to take into account studies done on elderly people vs a body builder on anabolics and abundant nutrition.
http://podplayer.net/?id=82862948
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