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Old 02-13-2019, 05:23 AM
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rss IGF - Time-dependent course of gastric ulcer healing and molecular markers profile mo

Time-dependent course of gastric ulcer healing and molecular markers profile modulated by increased gastric mucosal content of carbon monoxide released from its pharmacological donor.

Biochem Pharmacol. 2019 Feb 09;:

Authors: Magierowska K, Bakalarz D, Wójcik D, Chmura A, Hubalewska-Mazgaj M, Licholai S, Korbut E, Kwiecien S, Sliwowski Z, Ginter G, Brzozowski T, Magierowski M

Abstract
BACKGROUND AND PURPOSE: Besides hydrogen sulfide (H2S) and nitric oxide (NO), carbon monoxide (CO) contributes to the maintenance of gastric mucosal integrity. We investigated increased CO bioavailability effects on time-dependent dynamics of gastric ulcer healing mediated by particular growth factors, anti-inflammatory and molecular pathways.
EXPERIMENTAL APPROACH: Wistar rats with gastric ulcers induced by serosal acetic acid application (day 0) were treated i.g. throughout 3, 6 or 14 days with vehicle or CO-releasing tricarbonyldichlororuthenium (II) dimer (CORM-2, 2.5 mg/kg). Gross and microscopic alterations in gastric ulcer size and gastric blood flow (GBF) at ulcer margin were determined by planimetry, histology and laser flowmetry, respectively. Gastric mRNA/protein expressions of platelet derived growth factors (PDGFA-D), insulin-like growth factor (IGF-1), epidermal growth factor (EGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGFA) and their receptors, heme oxygenases (HMOX), nuclear factor (erythroid-derived 2)-like 2 (Nrf-2), cyclooxygenase (COX-2), hypoxia inducible factor (HIF)-1?, anti-inflammatory annexin-1 and transforming growth factor (TGF-?1) were assessed by real-time PCR or Western blot. TGF-?1-3 and IL-10 plasma concentration were measured using Luminex platform. Prostaglandin E2 content at ulcer margin was assessed by ELISA.
KEYRESULTS: CORM-2 decreased ulcer area and increased GBF after 6 and 14 days comparing to vehicle. CO donor upregulated HGF, HGFr, VEGFR1, VEGFR2, TGF-?1, annexin-1 and maintained increased IGF-1, PDGFC and EGF expression at time-intervals of ulcer healing. TGF-?3 and IL-10 plasma concentration were significantly increased after COMR-2 vs. vehicle.
CONCLUSIONS: CO time-dependently accelerates gastric ulcer healing and raises GBF at ulcer margin by mechanism involving subsequent upregulation of anti-inflammatory, growth promoting and angiogenic factors response, not observed physiologically.


PMID: 30753813 [PubMed - as supplied by publisher]



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