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Old 11-24-2019, 06:20 AM
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rss Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SA

Related Articles Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs.

Molecules. 2019 Nov 20;24(23):

Authors: Shao P, Zhou Y, Yang D, Wang MW, Lu W, Jin J

Abstract
The pentafluorosulfane (SF5) group, as a more electronegative bioisostere than the trifluoromethyl (CF3) group, has been gaining greater attention and increasingly reported usage in medicinal chemistry. Ostarine is the selective androgen receptor modulators (SARMs) containing a CF3 group in clinical trial III. In this study, 21 ostarine derivatives for replacing the CF3 group with SF5 substituents were synthesized. Some SF5-derivatives showed androgen receptor (AR) agonistic activities in vitro. The results pointed to the potential of using this scaffold to develop new AR agonists.


PMID: 31757115 [PubMed - in process]



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