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Old 06-14-2019, 08:27 AM
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rss Oral microemulsion based delivery system for reducing reproductive and kidney toxicit

Oral microemulsion based delivery system for reducing reproductive and kidney toxicity of Tripterygium glycosides.

J Microencapsul. 2019 Jun 13;:1-26

Authors: Wang J, Wang C, Wu J, Li Y, Hu X, Wen J, Cai J, Luo S, Liu X, Xiang D

Abstract
AIM: To reduce the toxic effects and achieve efficiency of Tripterygium glycosides, an oral microemulsion was designed.
METHOD: After estimating its stability and characterization, an animal experiment was held to evaluate its toxicity in vivo, using male and female Sprague Dawley rats.
RESULT: The maximum loading amount of microemulsion to Tripterygium glycosides was 18.87 mg/ml. And comparing to control, the Tripterygium glycoside microemulsion can maintain a normal level of the number of sperms, the weight of testicle, testosterone (~2.5 ng·mL-1) and BUN (~5 mmol· L-1) to male rats. For female rats, it can prevent the ovary to be atrophy and keep FSH to be stable (>2100 ng·L-1). The weaker injury induced by drug-loaded microemulsion to rats also could be observed in histological sections to kidney and reproductive organs.
CONCLUSIONS: Although the blank microemulsion had slight toxicity, it mitigated the toxicity of Tripterygium glycosides to kidney and reproductive system.


PMID: 31190589 [PubMed - as supplied by publisher]



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