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Medical and Physical Therapy questions A place to talk about current and or past injuries and possibly how to deal with those injuries. Any advice should not be considered as medical advice, but rather from one person to another as you might ask a friend.




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  #1  
Old 06-19-2017, 02:59 PM
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BPC-157 and TB500 for nerve damage, muscle injury and concussion

Hi,
I've recently learned about bp-157 and tb 500's ability to heal muscles, tendons, and even nerves. I've been struggling for a few years because of extreme noise sensitivity. I have nerve damage in my ears that makes noise painful. The concussion and whiplash have also made me noise sensitive. Are bp-157 and tb 500 the best options for healing? What about HGH? Or GHRP-6 and Ipam? I've been homebound for a few years because of the extreme noise sensitivity so would love to try these but not sure what to start with.
Thanks,
Rose
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Old 06-19-2017, 06:47 PM
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Where did you read about it healing nerves? I would like to read that study
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Old 06-20-2017, 10:09 AM
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Never heard it for nerve damage either. Using BPC-157, Ipamorelin and HGH to recovery from ACL surgery and surgery for a ruptured achilles and people think I'm Wolverine.
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Old 06-20-2017, 02:36 PM
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BPC-157 for nerve damege
US National Library of Medicine National Institutes of Health




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Regul Pept. 2010 Feb 25;160(1-3):33-41. doi: 10.1016/j.regpep.2009.11.005. Epub 2009 Nov 10.
Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury.
Gjurasin M1, Miklic P, Zupancic B, Perovic D, Zarkovic K, Brcic L, Kolenc D, Radic B, Seiwerth S, Sikiric P.
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Abstract

We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube. Improvement was shown clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals). BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers, existence of epineural and perineural regeneration, uniform target orientation of regenerative fibers, and higher proportion of neural vs. connective tissue, all fascicles in each nerve showed increased diameter of myelinated fibers, thickness of myelin sheet, number of myelinated fibers per area and myelinated fibers as a percentage of the nerve transected area and the increased blood vessels presentation), electrophysiologically (increased motor action potentials), functionally (improved SFI), the autotomy absent. Thus, BPC 157 markedly improved rat sciatic nerve healing.

Copyright 2009 Elsevier B.V. All rights reserved.

PMID:
19903499
DOI:
10.1016/j.regpep.2009.11.005

[Indexed for MEDLINE]
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Old 06-20-2017, 02:38 PM
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Journal ListCurr Neuropharmacolv.14(8); 2016 NovPMC5333585

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Curr Neuropharmacol. 2016 Nov; 14(8): 857–865.
Published online 2016 Nov. doi: 10.2174/1570159X13666160502153022
PMCID: PMC5333585
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
Predrag Sikiric,1,* Sven Seiwerth,1 Rudolf Rucman,1 Danijela Kolenc,1 Lovorka Batelja Vuletic,1 Domagoj Drmic,1 Tihomir Grgic,1 Sanja Strbe,1 Goran Zukanovic,1 Dalibor Crvenkovic,1 Goran Madzarac,1 Iva Rukavina,1 Mario Sucic,1 Marko Baric,1 Neven Starcevic,1 Zoran Krstonijevic,1 Martina Lovric Bencic,1 Igor Filipcic,1 Dinko Stancic Rokotov,1 and Josipa Vlainic2
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Abstract
Background

Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice.
Methods

Review of our research on BPC 157 in terms of brain-gut axis.
Results

BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated. Initially corresponding beneficial central influence was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed. BPC 157 modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Besides, BPC 157 has neuroprotective effects: protects somatosensory neurons; peripheral nerve regeneration appearent after transection; after traumatic brain injury counteracts the otherwise progressing course, in rat spinal cord compression with tail paralysis, axonal and neuronal necrosis, demyelination, cyst formation and rescues tail function in both short-terms and long-terms; after NSAIDs or insulin overdose or cuprizone encephalopathies were attenuated along with GI, liver and vascular injuries.
Conclusion

BPC 157, a gastric peptide, may serve as remedy in various CNS-disorders.
Keywords: Brain-gut axis, CNS-disorders, Stable gastric pentadecapeptide BPC 157, Therapy
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Old 06-20-2017, 09:54 PM
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Thanks Liftiron

I wonder if this would help with my optic atrophy
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