World Class Bodybuilding   Forum

BulkSupplements Egg Whites International A1Supplements.com i-Supplements Strength.com VitaSprings Myprotein Beyondsupplements
Go Back   World Class Bodybuilding Forum > Anabolic Steroid Discussion > Steroid Articles

Shoutbox
Loading...





Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 05-15-2018, 06:08 AM
Vision Vision Is Off Line
WCBB Veteran
 
Join Date: Apr 2018
Posts: 19
Thanks: 12
Thanked 6 Times in 6 Posts
Rep Power: 7
Vision is on a distinguished road
🌡️Test Flu and is it real (Yes and Here's why)🌡️

The topic "Test-Flu", Let's talk about it!

What is it, and do others experience it?

There's many factors to examine here.. Let's consider the age & genetics of the user,
the cycle/compounds being utilized and quantity/dosage..These are just a few examples to review!

Beyond anything else here: The question "test flu" can prove rather difficult to generalize because of so many variables at play here.
Such as the solvent/carrier used and ratio, quality and sterilization, or even remaining acidic residuels left behind in the raw material
from the manufacture cutting corners during the manufacturing process,
yielding poor quality which all my induce a lymphatic immune response.

This will differ from one instance to the next as well as the users sensitive will vary, and at times the route chosen for administration, sensitive injections sites..
Now, although we have a template here of what could possibly be taking place, there's an even more plausible explanation..

Keep in mind This all becomes dependent on the individual..There may not be a definitive answer for everyone,
but ultimately one should take great consideration the explanation that is about to be provided here.



Pyrogenicity of etiocholanolone and interleukin-1 in New and Old World Monkeys.

Abstract
Etiocholanolone (5beta-androstan-3alpha-ol-17-one; designated E) is one of the major products of metabolism of testosterone and
androstenedione (androst-4-ene-3,17-dione) in many mammalian species,including humans.
E and several other 5beta-reduced steroids have been found to induce fever in humans.
The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections.
Old World Monkeys such as Rhesus monkeys (Macaca mu/atta), metabolize androgens similarly to humans, and E is a normal metabolite.
However, New World Monkeys such as Squirrel monkeys (Saimiri sciureus),
lack hepatic 5alpha- and 5beta-steroid reductases and excrete androgens primarily in an unaltered state; E is not produced.
Therefore, we postulate that Squirrel monkeys likewise may have lost the ability to respond to 17-ketosteroids such as E. To test this hypothesis,
adult male Rhesus and Squirrel monkeys were treated with E, and their rectal temperatures were recorded over a 24-hr period.
Rhesus monkeys exhibited a rise of up to 3 degrees F following E injection. Squirrel monkeys, on the other hand,
did not exhibit any increase in rectal temperature over the 24-hr period, even when doses up to 250 times the effective human dose were used.
However, both species responded to injected IL-1alpha with a robust increase in rectal temperature.
The data show that E is pyrogenic in Rhesus, but not Squirrel monkeys.
The findings support the notion that injected E may induce release of IL-1 in Rhesus monkeys, but not in Squirrel monkeys.

Now Studies have shown that men are in fact more likely to get sick,
have a fever or contract the flu due to TESTOSTERONE levels..
So, the next time your girlfriend or wife calls you a baby, school here and don't feel so bad,
because the science/medical community understands how you feel!

I hope this information above provides some clarity on why some users report having "flu-like" symptoms
while utilizing Testostrone or other AAS.

Best regards,
Vision

__________________
"Please do NOT message me relating source information or questions, all PM's in this fashion will be reported"
Reply With Quote
The Following User Says Thank You to Vision For This Useful Post:
A1food4u (05-16-2018)
Get your liquid egg whites here at EGG WHITES INTERNATIONAL

  #2  
Old 05-15-2018, 06:37 AM
jipped genes's Avatar
jipped genes jipped genes Is online now
Moderator

 
Join Date: Feb 2004
Posts: 19,302
Thanks: 169
Thanked 2,918 Times in 2,232 Posts
Rep Power: 5052
jipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond reputejipped genes has a reputation beyond repute
wow that is interesting.
__________________
Never let a stranger take nude pictures of you in a rest stop bathroom.

It ain't what you don't know that gets you into trouble.
It's what you know for sure that just ain't so.
Reply With Quote
  #3  
Old 05-15-2018, 06:02 PM
liftsiron's Avatar
liftsiron liftsiron Is online now
Moderator

 
Join Date: Feb 2004
Location: Cimmeria
Posts: 5,141
Thanks: 28
Thanked 1,190 Times in 894 Posts
Rep Power: 914
liftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond reputeliftsiron has a reputation beyond repute
If anyone wants to review the full study.


Etiocholanolone is believed to produce fever and flu-like aches and pains because it induces the systemic release of Interleukin-1, a powerful proinflammatory cytokine:

Pyrogenicity of etiocholanolone and interleukin-1 in New and Old World Monkeys.

Steinetz BG, Randolph C, Werner R, Mahoney CJ.

New York University Medical Center, Laboratory for Experimental Medicine and Surgery in Primates, Tuxedo 10987, USA. steinetz@charlotte.med.nyu.edu

Etiocholanolone (5beta-androstan-3alpha-ol-17-one; designated E) is one of the major products of metabolism of testosterone and androstenedione (androst-4-ene-3,17-dione) in many mammalian species, including humans. E and several other 5beta-reduced steroids have been found to induce fever in humans. The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections. Old World Monkeys such as Rhesus monkeys (Macaca mu/atta), metabolize androgens similarly to humans, and E is a normal metabolite. However, New World Monkeys such as Squirrel monkeys (Saimiri sciureus), lack hepatic 5alpha- and 5beta-steroid reductases and excrete androgens primarily in an unaltered state; E is not produced. Therefore, we postulate that Squirrel monkeys likewise may have lost the ability to respond to 17-ketosteroids such as E. To test this hypothesis, adult male Rhesus and Squirrel monkeys were treated with E, and their rectal temperatures were recorded over a 24-hr period. Rhesus monkeys exhibited a rise of up to 3 degrees F following E injection. Squirrel monkeys, on the other hand, did not exhibit any increase in rectal temperature over the 24-hr period, even when doses up to 250 times the effective human dose were used. However, both species responded to injected IL-1alpha with a robust increase in rectal temperature. The data show that E is pyrogenic in Rhesus, but not Squirrel monkeys. The findings support the notion that injected E may induce release of IL-1 in Rhesus monkeys, but not in Squirrel monkeys.
__________________
__________________
ADMIN/OWNER@Peak-Muscle

Last edited by liftsiron; 05-15-2018 at 06:09 PM.
Reply With Quote
The Following 2 Users Say Thank You to liftsiron For This Useful Post:
A1food4u (05-16-2018), Vision (05-16-2018)
  #4  
Old 05-16-2018, 09:07 AM
Vision Vision Is Off Line
WCBB Veteran
 
Join Date: Apr 2018
Posts: 19
Thanks: 12
Thanked 6 Times in 6 Posts
Rep Power: 7
Vision is on a distinguished road
Quote:
Originally Posted by liftsiron View Post
If anyone wants to review the full study.


Etiocholanolone is believed to produce fever and flu-like aches and pains because it induces the systemic release of Interleukin-1, a powerful proinflammatory cytokine:

Pyrogenicity of etiocholanolone and interleukin-1 in New and Old World Monkeys.

Steinetz BG, Randolph C, Werner R, Mahoney CJ.

New York University Medical Center, Laboratory for Experimental Medicine and Surgery in Primates, Tuxedo 10987, USA. steinetz@charlotte.med.nyu.edu

Etiocholanolone (5beta-androstan-3alpha-ol-17-one; designated E) is one of the major products of metabolism of testosterone and androstenedione (androst-4-ene-3,17-dione) in many mammalian species, including humans. E and several other 5beta-reduced steroids have been found to induce fever in humans. The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections. Old World Monkeys such as Rhesus monkeys (Macaca mu/atta), metabolize androgens similarly to humans, and E is a normal metabolite. However, New World Monkeys such as Squirrel monkeys (Saimiri sciureus), lack hepatic 5alpha- and 5beta-steroid reductases and excrete androgens primarily in an unaltered state; E is not produced. Therefore, we postulate that Squirrel monkeys likewise may have lost the ability to respond to 17-ketosteroids such as E. To test this hypothesis, adult male Rhesus and Squirrel monkeys were treated with E, and their rectal temperatures were recorded over a 24-hr period. Rhesus monkeys exhibited a rise of up to 3 degrees F following E injection. Squirrel monkeys, on the other hand, did not exhibit any increase in rectal temperature over the 24-hr period, even when doses up to 250 times the effective human dose were used. However, both species responded to injected IL-1alpha with a robust increase in rectal temperature. The data show that E is pyrogenic in Rhesus, but not Squirrel monkeys. The findings support the notion that injected E may induce release of IL-1 in Rhesus monkeys, but not in Squirrel monkeys.
__________________
Fantastic addition.. THANK YOU for the data! (double thumbs up)
__________________
"Please do NOT message me relating source information or questions, all PM's in this fashion will be reported"
Reply With Quote
  #5  
Old 05-16-2018, 09:19 AM
A1food4u's Avatar
A1food4u A1food4u Is online now
Moderator


 
Join Date: Mar 2011
Location: between a soft and a hard place
Posts: 14,552
Thanks: 3,897
Thanked 3,437 Times in 2,741 Posts
Rep Power: 6319
A1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond reputeA1food4u has a reputation beyond repute
And knowledge was gained by all..
__________________
don't follow me... I'm lost
Reply With Quote
Reply

Bookmarks

Tags
test flu


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 06:30 AM.



Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
follow worldclassbodybuilding at facebook follow worldclassbodybuilding at pinterest follow worldclassbodybuilding at twitter