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  #1  
Old 10-27-2015, 07:13 AM
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Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves s

Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.


Previous studies have indicated the existence of common mechanisms regulating sleep and somatotropic activity. In the present study, we investigated the effects of prolonged treatment with a novel, orally active, growth hormone secretagogue (MK-677) on sleep quality in healthy young and older adults. Eight young subjects (18-30 years) followed a double-blind, placebo-controlled, three-period crossover design.

Each subject participated in three 7-day treatment periods (with bedtime drug administration), presented in random (Latin square) order, and separated by at least 14 days.
Doses were 5 and 25 mg MK-677 and matching placebo. Six older subjects, ages 65-71 years, each participated in two 14-day treatment periods (with bedtime drug administration) separated by a 14-day washout. Doses were 2 and 25 mg MK-677 during the first and second periods, respectively. Baseline sleep and hormonal data were obtained on the 2 days preceding the beginning of the first 14-day treatment period.
In young subjects, high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV and in a more than 20% increase in REM sleep as compared to placebo (p < 0.05). The frequency of deviations from normal sleep decreased from 42% under placebo to 8% under high-dose MK-677 (p < 0.03).
In older adults, treatment with MK-677 was associated with a nearly 50% increase in REM sleep (p < 0.05) and a decrease in REM latency (p < 0.02). The frequency of deviations from normal sleep also decreased (p < 0.02). The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence.
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  #2  
Old 10-27-2015, 06:47 PM
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I feel that it works.
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Old 10-27-2015, 10:16 PM
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Any for real life studies on this or is it just all marketing BS.
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Old 12-06-2017, 01:26 PM
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Just started taking it again. I sleep deep. The lucid dreams are fun!
Feel great
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Old 12-08-2017, 11:43 AM
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Just for the benefits of sleep would be worth it to me.
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Old 12-08-2017, 11:52 AM
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i just read the first two words of he title and jumped in here. what a disappointment
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Old 12-08-2017, 12:30 PM
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TOTAL opposite effect for me, wicked insomnia almost from day one.
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Old 12-08-2017, 12:40 PM
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Quote:
Originally Posted by acneman View Post
i just read the first two words of he title and jumped in here. what a disappointment
Prolonged oral treatment: Hilarious!
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