World Class Bodybuilding   Forum

BulkSupplements Egg Whites International A1Supplements.com i-Supplements Strength.com VitaSprings Myprotein Beyondsupplements
Go Back   World Class Bodybuilding Forum > WorldClass RSS Feeds > Peptides RSS FFEDS




Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 06-28-2020, 05:14 AM
Bodybuilding Peptides's Avatar
Bodybuilding Peptides Bodybuilding Peptides Is Off Line
Sponsor

 
Join Date: Feb 2009
Posts: 6,515
Thanks: 1
Thanked 32 Times in 23 Posts
Rep Power: 222
Bodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to behold
rss IGF - IGF-1 treatment causes unique transcriptional response in neurons from individu

Related Articles IGF-1 treatment causes unique transcriptional response in neurons from individuals with idiopathic autism.

Mol Autism. 2020 Jun 26;11(1):55

Authors: Linker SB, Mendes APD, Marchetto MC

Abstract
BACKGROUND: Research evidence accumulated in the past years in both rodent and human models for autism spectrum disorders (ASD) have established insulin-like growth factor 1 (IGF-1) as one of the most promising ASD therapeutic interventions to date. ASD is phenotypically and etiologically heterogeneous, making it challenging to uncover the underlying genetic and cellular pathophysiology of the condition; and to efficiently design drugs with widespread clinical benefits. While IGF-1 effects have been comprehensively studied in the literature, how IGF-1 activity may lead to therapeutic recovery in the ASD context is still largely unknown.
METHODS: In this study, we used a previously characterized neuronal population derived from induced pluripotent stem cells (iPSC) from neurotypical controls and idiopathic ASD individuals to study the transcriptional signature of acutely and chronically IGF-1-treated cells.
RESULTS: We present a comprehensive list of differentially regulated genes and molecular interactions resulting from IGF-1 exposure in developing neurons from controls and ASD individuals. Our results indicate that IGF-1 treatment has a different impact on neurons from ASD patients compared to controls. Response to IGF-1 treatment in neurons derived from ASD patients was heterogeneous and correlated with IGF-1 receptor expression, indicating that IGF-1 response may have responder and non-responder distinctions across cohorts of ASD patients. Our results suggest that caution should be used when predicting the effect of IGF-1 treatment on ASD patients using neurotypical controls. Instead, IGF-1 response should be studied in the context of ASD patients' neural cells.
LIMITATIONS: The limitation of our study is that our cohort of eight sporadic ASD individuals is comorbid with macrocephaly.in childhood. Future studies will address weather downstream transcriptional response of IGF-1 is comparable in non-macrocephalic ASD cohorts.
CONCLUSIONS: The results presented in this study provide an important resource for researchers in the ASD field and underscore the necessity of using ASD patient lines to explore ASD neuronal-specific responses to drugs such as IGF-1. This study further helps to identify candidate pathways and targets for effective clinical intervention and may help to inform clinical trials in the future.


PMID: 32591005 [PubMed - as supplied by publisher]



More...
Insulin like growth factors
IGF-1
Igf-1r3

This has been a World Class Bodybuilding automated thread
__________________
W C B B Affiliates

PowderCity.com <---Best Selling Products
BulkSupplements.com <---Save Money, Buy in BULK
IslandSupplements.com <--- Latest Sale Items
I-supplements.com <--- Vip Special Offers
A1Supplements.com <----Clearance Supplements
HideMyAss Security Proxy<---- Protect your online activity
Home Chemistry Conversions <-- home chemistry needs
Help WCBB by using our AMAZON.com link use for any amazon purchase.
Egg Whites International <---100% Bio-Available Egg White Protein
Liquid egg whites recipes ,-- protein shakes, smoothies, full delicious meals etc.
Egg White Fitness Website <-- Site all about Egg Whites
WorldClassBodyBuilding Teeshirts <-- get your WCBB t-shirts here, first design to latest
Reply With Quote
Get your liquid egg whites here at EGG WHITES INTERNATIONAL

Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 06:43 PM.



Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
follow worldclassbodybuilding at facebook follow worldclassbodybuilding at pinterest follow worldclassbodybuilding at twitter