IGF - How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life
Related Articles How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude.
Cell Rep. 2017 Apr 18;19(3):441-450
Authors: Podshivalova K, Kerr RA, Kenyon C
The goal of aging research is to extend healthy, active life. For decades, C..elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness. However, a recent report suggested that their longevity is associated with an undesirable.phenotype: a disproportionately long period of decrepitude at the end of life. In the human population, such an outcome would be a burden to society, bringing into question the relevance of daf-2 mutants as a model for life extension. However, here we report that, following an extended period of movement, daf-2 mutants survive longer in a decrepit state because of a beneficial trait: they are resistant to colonization of the digestive tract by dietary bacteria, a condition that leads to premature death in the wild-type and prevents their manifestation of decrepitude. If bacterial colonization is prevented, then daf-2 mutants lead both chronologically and proportionately healthier lives relative to the wild-type.
PMID: 28423308 [PubMed - in process]
Insulin like growth factors
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