World Class Bodybuilding   Forum

BulkSupplements Powder City Egg Whites International A1Supplements.com i-Supplements HideMyAss
Go Back   World Class Bodybuilding Forum > WorldClass RSS Feeds > Testosterone RSS feeds




Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 02-17-2017, 10:02 AM
basskiller's Avatar
basskiller basskiller Is online now
Administrator

 
Join Date: Jan 2004
Location: Bodybuilding heaven
Posts: 116,923
Thanks: 3,148
Thanked 17,060 Times in 9,936 Posts
Rep Power: 2822
basskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond reputebasskiller has a reputation beyond repute
rss Imidacloprid induces various toxicological effects related to the expression of 3?-HS

Related Articles Imidacloprid induces various toxicological effects related to the expression of 3?-HSD, NR5A1, and OGG1 genes in mature and immature rats.

Environ Pollut. 2017 Feb;221:15-25

Authors: Abdel-Rahman Mohamed A, Mohamed WA, Khater SI

Abstract
This study aimed to evaluate the adverse effects of the insecticide imidacloprid (IMI) on male spermatogenesis, steroidogenesis, and DNA damage in sexually mature and immature rats. Forty male rats (mature and immature) were equally divided into four groups: two mature and two immature groups. IMI groups of both ages were orally administered IMI in corn oil at a concentration of 1.mg/mL for kg BW/day, whereas their respective controls were orally administered corn oil only (1.mL/kg of body weight) daily for 65 days. On day 66, the rats were lightly anesthetized and then euthanized by cervical dislocation. Whole blood was collected for hemogram, serum for hormonal profile, semen for sperm profile, and testes for gene expression and histopathological, and immunohistochemical examinations. The obtained results revealed that both sexually mature and immature rats orally exposed to IMI showed serious abnormalities in sperm morphology and concentrations, with an imbalance of sexual hormones. There were increases in the level of serum 8-hydroxy-2'-deoxyguanosine and in the percentage of comet (tailed) sperm DNA in the IMI-treated groups. The results exhibited the upregulation of a DNA damage tolerance gene (8-oxoguanine glycosylase 1) and downregulation of the activity of steroidogenic genes (nuclear receptor subfamily 5, group A, member 1 and 3?-hydroxysteroid dehydrogenase). Immunohistochemical examination of the B-cell lymphoma 2-associated X apoptotic protein in testicular sections showed various degrees of apoptosis in the spermatogonial cells of the IMI-treated rats compared to the control groups. These damaging effects of IMI were more pronounced in the sexually mature rats than in the immature rats. In conclusion, despite using a low dose of IMI in the present study, there were noticeable harmful consequences on the reproductive system at different stages of sexual maturity in male rats.


PMID: 27914857 [PubMed - indexed for MEDLINE]



This is an automated post
__________________

W C B B Sponsors
Precisionpinz
Species Nutrition
Suppz.com - Bodybuilding Supplement Superstore

W C B B Affiliates
PowderCity.com
BulkSupplements.com
IslandSupplements.com
I-supplements.com
A1Supplements.com
HideMyAss Security Proxy<---- Protect your online activity
Home Chemistry Conversions
Egg Whites International <---100% Bio-Available Egg White Protein


Remember... Any advice given on this board is just an opinion and not to be taken as medical advice. WCBB doesn't advocate or condone use of steroids. Check the laws in your country. WCBB just provides the platform in which to discuss such matters
Reply With Quote
Get your liquid egg whites here at EGG WHITES INTERNATIONAL

Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -4. The time now is 11:45 AM.



Copyright ©2000 - 2017, Jelsoft Enterprises Ltd.
follow worldclassbodybuilding at facebook follow worldclassbodybuilding at pinterest follow worldclassbodybuilding at twitter