World Class Bodybuilding   Forum

BulkSupplements Egg Whites International A1Supplements.com i-Supplements Strength.com VitaSprings Myprotein Beyondsupplements
Go Back   World Class Bodybuilding Forum > WorldClass RSS Feeds > Peptides RSS FFEDS




Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 08-15-2019, 06:07 AM
Bodybuilding Peptides's Avatar
Bodybuilding Peptides Bodybuilding Peptides Is Off Line
Sponsor

 
Join Date: Feb 2009
Posts: 6,124
Thanks: 1
Thanked 32 Times in 23 Posts
Rep Power: 210
Bodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to beholdBodybuilding Peptides is a splendid one to behold
rss IGF - Dual effects of an anti-CD147 antibody for Esophageal cancer therapy.

Dual effects of an anti-CD147 antibody for Esophageal cancer therapy.

Cancer Biol Ther. 2019 Aug 14;:1-10

Authors: Wang M, Zhang S, Sun Q, Yang X, Wang Y, Shang R, Zhu Y, Yao H, Li Y

Abstract
Background: Esophageal cancer is a highly aggressive neoplasm. Targeted therapy has been proven to be a promising way for cancer therapy. Here, we report a novel anti-CD147 antibody for esophageal cancer therapy, which is a chimeric antibody with modified glycoform in Fc region. Methods: ADCC assay was used to explore the antitumor efficacy of Metuzumab against esophageal cancer in vitro. Wound healing assay and Boyden Chamber invasion assay were performed to explore whether Metuzumab could inhibit migration and invasion of esophageal cancer in vitro. Insulin-like growth factors 1 (IGF-1) and PI3k/Akt was assayed for elaborating antagonistic mechanism of Metuzumab in migration and invasion of esophageal cancer cells. Subcutaneous xenograft nude mouse model was used to investigate the antitumor efficacy of Metuzumab against esophageal cancer in vivo. The esophageal cancer tissue microarrays (TMA) was examined for identification of association of CD147 with lymph node metastasis, and the footpad xenograft nude mouse model was used to explore whether Metuzumab could inhibit lymph node metastasis of esophageal cancer in vivo. Results: The results showed that Metuzumab exhibited higher ADCC compared to the wild type antibody cHAb18. Metuzumab inhibited migration and invasion of esophageal cancer through blockade of CD147 in vitro. The results of Western blot showed Metuzumab might inhibit migration and invasion of esophageal cancer cells through suppressing activation of PI3k/Akt and expression of IGF-1. Experiments in vivo showed that Metuzumab exhibited significant antitumor efficacy and inhibited lymph node metastasis of esophageal cancer in xenograft models. The immunochemical staining of TMA showed CD147 was high-expressed on various kinds of esophageal cancer tissues and associated with the grade of lymph node-metastasis. Conclusions: The in vitro and in vivo study demonstrated dual effects of Metuzumab in effectively mediating ADCC by activating effector cells, and inhibiting metastasis of esophageal cancer through blockade the function of CD147, providing justification for moving Metuzumab forward to clinical development in esophageal cancer.


PMID: 31411555 [PubMed - as supplied by publisher]



More...
Insulin like growth factors
IGF-1
Igf-1r3

This has been a World Class Bodybuilding automated thread
__________________
W C B B Affiliates

PowderCity.com <---Best Selling Products
BulkSupplements.com <---Save Money, Buy in BULK
IslandSupplements.com <--- Latest Sale Items
I-supplements.com <--- Vip Special Offers
A1Supplements.com <----Clearance Supplements
HideMyAss Security Proxy<---- Protect your online activity
Home Chemistry Conversions <-- home chemistry needs
Help WCBB by using our AMAZON.com link use for any amazon purchase.
Egg Whites International <---100% Bio-Available Egg White Protein
Liquid egg whites recipes ,-- protein shakes, smoothies, full delicious meals etc.
Egg White Fitness Website <-- Site all about Egg Whites
WorldClassBodyBuilding Teeshirts <-- get your WCBB t-shirts here, first design to latest
Reply With Quote
Get your liquid egg whites here at EGG WHITES INTERNATIONAL

Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 06:02 PM.



Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.
follow worldclassbodybuilding at facebook follow worldclassbodybuilding at pinterest follow worldclassbodybuilding at twitter