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Old 08-20-2019, 05:03 AM
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rss IGF - Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus.

Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus.

Physiol Res. 2019 Aug 19;

Authors: Anderlová K, Cinkajzlová A, Šimják P, Klou?ková J, Kratochvílová H, Lacinová Z, Kaválková P, Krej?í H, Mráz M, Pa?ízek A, Haluzík M, Kršek M


Abstract
The insulin-like growth factor (IGF) is involved in the regulation of growth and metabolism. The aim of this study was to determine selected parameters of IGF system at systemic and local levels [subcutaneous (SAT) and visceral adipose tissue (VAT)] to assess its possible role in gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM and 16 without GDM) and 15 age-matched non-pregnant females were included in the study. Blood samples were taken in 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. SAT and VAT samples were obtained during delivery or surgery. Compared with non-pregnant women, serum IGF-1 and IGFBP-3 were increased in both groups of pregnant women. IGF-2 was elevated only in GDM women from 36 weeks of gestation culminating 6 months after delivery (p=0.003). Serum IGFBP-3 was increased and IGFBP-4 decreased in GDM women vs. pregnant women without GDM during the whole study (IGFBP-3: p
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