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Old 11-11-2017, 07:39 AM
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rss IGF - RNAi targeting Caenorhabditis elegans ?-arrestins marginally affects lifespan.

RNAi targeting Caenorhabditis elegans ?-arrestins marginally affects lifespan.

F1000Res. 2017;6:1515

Authors: Park S, Jung Y, An SWA, Son HG, Hwang W, Lee D, Artan M, Park HH, Jeong DE, Lee Y, Lee SV

Abstract
Background: ?-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of ?-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans ?-arrestins had small or no effects on lifespan. Thus, individual C. elegans ?-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of ?-arrestins in aging and longevity.


PMID: 29123644 [PubMed]



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