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Old 01-08-2022, 05:07 PM
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Does anyone have experience with glycine?

I want to know the best time to take glycine. In various articles, I've read post workout with creatine and or carbs (glucose, for example) for bodybuilding purposes; I've read at bedtime for deeper sleep and gh release; and I've read it can be spread throughout the day.

Being diabetic, I don't take carbs immediately after my workout, just protein, creatine, glutamine & BCAAs. So a follow-on to my question is, does the body store glycine so timing doesn't matter so much or does it dissapate too quickly?
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Old 01-09-2022, 10:28 AM
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Bro, I take glycine and gaba at night before bed with melatonin. I would think if you took it during the day it would not help you sleep.
Whey protein has glycine in it already. Granted for about 20 grams of powder it might have 400-500 mg of glycine.

That is all I know.
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Old 01-12-2022, 04:44 AM
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That's helpful. I also am looking at glycine from a diabetic perspective. My particular diabetes is due to over production of blood glucose. Glycine seems to significantly suppress blood glucose while not affecting insulin levels.
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Old 01-12-2022, 03:11 PM
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There was something I was reading that it does if you take too much, or not with something else, and I can't remember what it was. I'll have to go and read back up on it.

I would also recommend collagen powder, as it will be rich in glycine, and may have a better delivery of absorption. I use TN's beef collagen powder. Actually, IIRC, you don't live in the States? Man, i'm slipping. I'm not sure of the availability elsewhere though.
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Old 01-13-2022, 07:33 PM
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https://pubmed.ncbi.nlm.nih.gov/35013990/

J Endocrinol Invest. 2022 Jan 11. doi: 10.1007/s40618-021-01720-3.

Effects of glycine on metabolic syndrome components: a review
M Imenshahidi 1 2, H Hossenzadeh 3 4
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PMID: 35013990 DOI: 10.1007/s40618-021-01720-3

Abstract
Purpose: Glycine is the simplest and major amino acid in humans. It is mainly generated in the liver and kidney and is used to produce collagen, creatine, glucose and purine. It is also involved in immune function, anti-inflammatory processes and anti-oxidation reactions. Here, we reviewed the current evidence supporting the role of glycine in the development and treatment of metabolic syndrome components.

Methods: We searched Scopus, PubMed and EMBASE databases for papers concerning glycine and metabolic syndrome.

Results: Available evidence shows that the amount of glycine synthesized in vivo is insufficient to meet metabolic demands in these species. Plasma glycine levels are lower in subjects with metabolic syndrome than in healthy individuals. Interventions such as lifestyle modification, exercise, weight loss, or drugs that improve manifestations of metabolic syndrome remarkably increase circulating glycine concentrations.

Conclusion: Glycine supplementation improves various components of metabolic syndrome including diabetes, obesity, hyperlipidemia and hypertension. In the future, the use of glycine may have a significant clinical impact on the treatment of patients with metabolic syndrome.
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