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Old 03-21-2017, 07:30 AM
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rss Exercise Improves V[Combining Dot Above]O 2max and Body Composition in ADT-treated Pr

Related Articles Exercise Improves V[Combining Dot Above]O 2max and Body Composition in ADT-treated Prostate Cancer Patients.

Med Sci Sports Exerc. 2017 Mar 18;:

Authors: Wall BA, Galvăo DA, Fatehee N, Taaffe DR, Spry N, Joseph D, Hebert JJ, Newton RU


Abstract
INTRODUCTION: Prostate cancer is the most common cancer in men and patients treated with androgen deprivation therapy (ADT) experience unfavourbale changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition and cardiorespiratory health in this population.
METHODS: Ninety-seven men (43-90 years) with localized prostate cancer receiving ADT were randomized to either exercise (EX, n=50) or usual care (CON, n=47). Supervised exercise was undertaken twice-weekly at moderate-to-high intensity. Measures of cardiorespiratory capacity (V[Combining Dot Above]O2max), resting metabolic rate, central blood pressure, hemodynamic variables, blood markers, and body composition were assessed.
RESULTS: There was a significant group by time interaction present for V[Combining Dot Above]O2max (p=0.033) with a treatment effect for EX of 0.11 (95% CI, 0.04-0.19) L.min [relative to body mass 1.3 (95% CI, 0.3-2.3) ml.kg.min], and fat oxidation (p=0.037) of 12.0 (95% CI, 2.3-21.7) mg.min. Similarly, there was a significant improvement in glucose (p
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