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Old 08-30-2012, 07:50 AM
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rss Human Growth Hormone - Endogenous growth hormone and insulin after interposition of a

BMC Res Notes. 2012 Aug 28; 5(1): 463
Papamichail M, Digalakis M, Panagiotis P, Paisios O, Loti S, Sergentanis T
ABSTRACT: BACKGROUND: Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiology, intervene on this effect. FINDINGS: Porcine models were randomly allocated to two cohorts: (1) short bowel (SB) group (n = 8) and (2) short bowel reverse jejunal segment (SB-RS) group (n = 8). Amongst other parameters serum growth hormone and insulin were measured at baseline, as well as on postoperative day 30 and 60. CONCLUSION: Both endogenous hormones failed to demonstrate significant difference in respect to potential direct effect to mechanisms of enhanced intestinal adaptation in reversed group.

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